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Consultant in Clinical Pharmacology and Therapeutics and General Internal Medicine

Clinical interests

Dr Threapleton’s clinical interests involve working with patients and healthcare professionals to manage complex long term health conditions and polypharmacy (the use of multiple medicines).  He established and leads the Polypharmacy Service at St George’s.

Academic interests

Dr Threapleton is a senior clinical lecturer at City St George’s, University of London.  His primary research interests are the culture and practice of prescribing and the management of patients with polypharmacy.  His PhD included an international systematic review of factors associated with polypharmacy, regression modelling of the influences of prescribing practice in SW London and healthcare innovation research into how clinical pharmacologists could support safe and effective prescribing for people with problematic polypharmacy, leading to the launch of the Polypharmacy Service in 2021.

Dr Threapleton established and leads the 18-month Drugs in Healthcare module and the clinical skills teaching on the Clinical Pharmacology BSc and provides additional undergraduate and postgraduate teaching.

Professional profile

Dr Threapleton qualified from Newcastle University with a BSc Psychology in 2009 and MBBS Medicine and Surgery in 2013.  He achieved membership to the Royal College of Physicians in 2016.  He was appointed as a consultant in Clinical Pharmacology and Therapeutics and General Internal Medicine in 2024.

Memberships, fellowships and awards

Fellow of the British Pharmacological Society, FBPhS

Fellow of the Higher Education Academy, FHEA

Member of the Royal College of Physicians (London)

Excellence in Healthcare Education Award, St George’s University Hospitals NHS Foundation Trust, 2018

Education Excellence Award, St George’s, University of London, 2020

 

Publications

Click here to view Dr Threapleton’s ResearchGate profile

(in reverse chronological order)

Threapleton CJD, Harris T, Baker EH. Stratifying patients for polypharmacy interventions: The case for a new biomarker? [published online ahead of print, 2021 Oct 1]. Br J Clin Pharmacol. 2021;10.1111/bcp.15083. doi:10.1111/bcp.15083.

Janjua S, Carter D, Threapleton CJ, Prigmore S, Disler RT. Telehealth interventions: remote monitoring and consultations for people with chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev. 2021;7(7):CD013196. Published 2021 Jul 20. doi:10.1002/14651858.CD013196.pub2.

Janjua S, Banchoff E, Threapleton CJD, Prigmore S, Fletcher J, Disler RT. Digital interventions for the management of chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2021, Issue 4. Art. No.: CD013246. DOI: 10.1002/14651858.CD013246.pub2.

Janjua S, Mathioudakis AG, Fortescue R, Walker RA, Sharif S, Threapleton CJ, Dias S. Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis. Cochrane Database Syst Rev. 2021 Jan 15;1:CD013198.

Threapleton CJD, Kimpton JE, Carey IM, DeWilde S, Cook DG, Harris T, Baker EH. Development of a structured clinical pharmacology review for specialist support for management of complex polypharmacy in primary care. Br J Clin Pharmacol. 2020 Jul;86(7):1326-1335.

Khong TK, Threapleton CJD. Prescribing of anticholinergic medicines to patients initiating dementia medicines. Drug Ther Bull. 2020;58(6):83‐84.

Khong TK, Threapleton CJD. Discharging doctors do not reliably predict risk of medication-related harm. Drug Ther Bull. 2019;57(7):102‐103.

Kimpton JE, Carey IM, Threapleton CJD, et al. Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. Br J Clin Pharmacol. 2019;85(12):2734‐2746.

Threapleton CJ, Janjua S, Fortescue R, Baker EH. Head-to-head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2019;5(5):CD013024

Walker RW, Churm D, Dewhurst F, Samuel M, Ramsell A, Lawrie C, Hill J, Threapleton CJ, Wood B, Gray WK. Palliative care in people with idiopathic Parkinson’s disease who die in hospital, BMJ Support Palliat Care. 2014 Mar;4(1):64-7.

Robinson LJ, Stevens LH, Threapleton CJ, Vainiute J, McAllister-Williams RH, Gallagher P. Effects of intrinsic and extrinsic motivation on attention and memory. Acta Psychol (Amst). 2012.