• Professor of Neurosurgery

    Contact

    Email: mpapadop@sgul.ac.uk

    Secretary: Sam Rutledge

    Secretary email: samantha.rutledge@stgeorges.nhs.uk

    Secretary telephone: 020 8725 4179

    Clinical interests

    Prof Papadopoulos is a consultant neurosurgeon with a specialist interest in complex spinal surgery and vascular neurosurgery.

    His clinical interests include general neurosurgery with sub-specialist interest in vascular and complex spinal surgery.

    His research interests are aquaporin water channel proteins, especially aquaporin-4. His laboratory investigates the role of aquaporin-4 in brain and spinal cord swelling and in the neurological disease neuromyelitis optica. Prof Papadopoulos is also interested in the role of spinal cord swelling after injury and has set up the ISCoPE (Injured Spinal Cord Pressure Evaluation) clinical study aiming to develop novel techniques to manage spinal cord swelling after sever traumatic spinal cord injury.

    A full list of Prof Papadopoulos' research publications is available here.

    Professional profile

    Professor Papadopoulos was educated at the Universities of Cambridge (BA 1990, MD 1997) and Oxford (BM BCh 1993).  He became a Fellow of the Royal College of Surgeons (FRCS) in 1998 and a Fellow of the Royal College of Surgeons in Surgical Neurology (FRCS(SN)) in 2002.  Prof Papadopoulos received his Certificate of Completion of Specialist Training (CCST) in Neurosurgery in 2005.

    Neurosciences Research Foundation

    Prof Papadopoulos is Chairman of the Neurosciences Research Foundation, which funds patient-centred research in clinical neurosciences.

    The Neurosciences Research Foundation is supported by the generous donations from patients who were treated at Atkinson Morley at St George's Hospitals.

    To make a donation to the Neurosciences Research Foundation visit www.neurosciencesresearchfoundation.org.uk

    Consultant Outcome Publication 2014

    Read the National Neurosurgical Audit Programme mortality data and outcome report for Prof Papadopoulos

    Recent publications

    Verkman AS, Anderson MO, Papadopoulos MC. Aquaporins, important but elusive drug targets. Nature Reviews Drug Discovery (in press).

    Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos G, Czosnyka Z, Smielewski P, Jamous A, Anthony BA, Zoumprouli A, Papadopoulos MC. Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the ISCoPE study. Critical Care Medicine (in press).

    Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013;14:265-77.

    Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. Lancet Neurol. 2012;11:535-44.

    Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol. 2012;71:323-33.

    Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol. 2012;71:314-22.

    Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC.
    Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain. 2010;133:349-61.

    Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008;131:1087-98.

    Tait MJ, Saadoun S, Bell BA, Papadopoulos MC. Water movements in the brain: role of aquaporins. Trends Neurosci. 2008;31:37-43.

    Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005;118:5691-8.

    Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92.

    Papadopoulos MC, Verkman AS. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem. 2005; 280:13906-12.

    Favourites

    Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC.
    Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain. 2010;133:349-61.

    Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92.

    Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004;18:1291-3.