Professor of Neurosurgery

Neurosciences Research Foundation

Prof Papadopoulos is Chairman of the Neurosciences Research Foundation, which funds patient-centred research in clinical neurosciences.

The Neurosciences Research Foundation is supported by the generous donations from patients who were treated at Atkinson Morley at St George's Hospitals.

To make a donation to the Neurosciences Research Foundation visit www.neurosciencesresearchfoundation.org.uk

Consultant Outcome Publication 2014

Read the National Neurosurgical Audit Programme mortality data and outcome report for Prof Papadopoulos

Recent publications

Verkman AS, Anderson MO, Papadopoulos MC. Aquaporins, important but elusive drug targets. Nature Reviews Drug Discovery (in press).

Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos G, Czosnyka Z, Smielewski P, Jamous A, Anthony BA, Zoumprouli A, Papadopoulos MC. Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the ISCoPE study. Critical Care Medicine (in press).

Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nat Rev Neurosci. 2013;14:265-77.

Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. Lancet Neurol. 2012;11:535-44.

Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann Neurol. 2012;71:323-33.

Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol. 2012;71:314-22.

Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC.
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain. 2010;133:349-61.

Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008;131:1087-98.

Tait MJ, Saadoun S, Bell BA, Papadopoulos MC. Water movements in the brain: role of aquaporins. Trends Neurosci. 2008;31:37-43.

Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005;118:5691-8.

Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92.

Papadopoulos MC, Verkman AS. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem. 2005; 280:13906-12.

Favourites

Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC.
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain. 2010;133:349-61.

Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92.

Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004;18:1291-3.