Prof. Marios Papadopoulos is the academic neurosurgeon at St. George’s. He is also the Head of the Neurosciences Centre within St. George’s University of London. There are several research fellows and graduate students in the department.
Current research projects include:
Novel monitoring to optimize the early management of patients with severe spinal cord injury
In collaboration with Dr. Argyro Zoumprouli (intensive care) and Prof. Marek Czosnyka’s group in Cambridge, Prof. Papadopoulos has developed techniques to monitor intraspinal pressure and spinal cord perfusion pressure after spinal cord injury. This is analogous to monitoring intracranial pressure and cerebral perfusion pressure after brain injury.
Developing novel surgical techniques to improve outcome after spinal cord injury
Prof. Papadopoulos’ group has developed a novel surgical technique termed expansion duroplasty, which redcues the pressure on the injured spinal cord after injury.
Spinal cord regeneration
Prof. Geoffrey Raisman has recently been appointed to help develop surgical techniques to implant olfactory ensheathing cells into the damaged spinal cord to promote regeneration. Prof. Raisman has developed this technique and has recently shown that it works in humans. This was the subject of a recent BBC Panorama programme.
For further details see Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging
MR spectroscopy of brain tumours
Prof. Franklyn Howe has developed MRI-based techniques to help diagnose brain tumours non-invasively. Some of these techniques are used clinically, e.g. to target the most aggressive part of a glioma for biopsy.
Diffusion-weighted MR of brain
Dr. Thomas Barrick uses diffusion-weighted MRI to map out the white matter tracts in the brain. Some of these techniques are used clinically e.g. to define the relationship between a brain lesion and associated white matter tracts.
Prof. Papadopoulos’ laboratory investigates the roles of aquaporin water channels in the brain and spinal cord. In collaboration with Alan Verkan in San Francisco, they have characterized the role of aquaporins in brain oedema and cell migration. A major goal of his laboratory is to understand the role of aquaporin-4 in neuromelitis optical and develop novel treatments. For further information see Treatment of neuromyelitis optica state-of-the-art and emerging therapies