Intensive Care Research

The Critical Care Directorate of St George’s Hospital is world renowned for its research and educational activities.

Research Team.

Dr. Maurizio Cecconi – Research Lead

Dr. Andrew Rhodes

Dr. Hollmann D. Aya

Mr. Johannes Mellinghoff

Ms. Christine Ryan

Mr. Narenduth Poonuth


Professor David Bennett (1938-2012) was one of the pioneers of intensive care around the world. He carried out research in the management of high-risk surgical patients. Peri-operative goal directed therapy was one of the main achievements of Prof. Bennett, reducing the risk of postoperative complications and death in this group of patients. Since then, many current intensive care world leaders have been in St George’s critical care during their training period, and the research has been expanded and diversified achieving international recognition.

Our scientific production has increased steadily over the last 10 years and several members of our team hold, or have held, senior positions in international and national scientific societies and high impact factor journals in the field of Intensive Care, Anaesthesia and Perioperative Medicine and Nursing. In cooperation with St. George’s University of London we currently supervise MD(res) and PhD Students and we offer research fellowships to part-time and full time clinical and research fellows.

Our main areas of interest are:

  • Cardiovascular Physiology and Pathophysiology
  • Haemodynamic Monitoring
  • Sepsis and septic shock
  • Acute Kidney Injury
  • ICU Outcomes
  • Cost-effectiveness analysis of healthcare
  • Perioperative Outcomes
  • Goal Directed Therapy
  • Meta-analysis
  • Risk Stratification
  • Acoustics

The Critical Care directorate participates in several studies adopted by the National Institute of Health Research (NIHR)

Current Research:

These are some of our research projects. Please ask a member of our team if you want further information.

Title Summary Population target Contact

JREO: 13.0036

This is an international clinical trial to find out if hydrocortisone (an anti-inflammatory medication) can reduce mortality and complications in patients with septic shock Patients suffering septic shock Dr. Hollmann Aya

Dr. Andy Rhodes


JREO: 12.0093

This is a multicentre clinical trial investigating the impact of the type of medication used to maintain blood pressure (Noradrenaline vs Vasopressin) on mortality and recovery of patients with sepsis Patients suffering septic shock Mr. Johanness Mellinghoff

Dr. Hollmann Aya

Dr. Maurizio Cecconi

Minimal volume for Septics


This study is a randomised control trial looking for the minimal volume of intravenous fluids that is required to perform a fluid challenge that can increase the mean systemic filling pressure, using a non-invasive method to measure this haemodynamic parameter. It will also study changes in the microcirculation using the most sophisticated technology to study tissue perfusion Patient suffering sepsis or septic shock Dr. Hollmann Aya

Dr. Maurizio Cecconi



Severe illness can change the way that the body handles (metabolises) drugs. At the moment all patients are given the same dose of antibiotics regardless of age, weight or how sick they are. ABDose aims to measure antibiotic concentrations to investigate variability in antibiotic concentrations and the causes of this. Critically ill patients requiring antibiotic therapy Dr. Dagan Londsdale

Dr. Barbara Philips

IOSwean This is an international observational study that investigates the process of recovering the normal breathing after being sedated and requiring mechanical ventilation. Critical ill patients requiring mechanical ventilation Dr. Susannah Leaver

Ms. Chris Ryan




This a post-marked safety study looking at the reformulated dialysis fluid use in patients with kidney failure in critical care. Patients requiring continuous renal replacement therapy Dr. Maurizio Cecconi

Ms. Chris Ryan


You can find further information of our recent publications on