ED Clinical Research Unit – publications

Below are the publications from academic and clinical staff working in the Emergency Department. Links to the full text papers are included where these are freely available.

2020 publications (alphabetical)

Alghamdi A, Reynard C, Morris N, Moss P, Jarman H, Hardy E, Harris T, Horner D, Parris R, Body R. Diagnostic accuracy of the Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid with a point-of-care cardiac troponin assay Emergency Medicine Journal 2020;37(4):223-228 doi.org/10.1136/emermed-2019-208882

Goodacre S, Walters S, Qayyum H, Coffey F, Carlton E, Coats T, Glazebrook W, Unitt L. Diagnostic accurarcy of magnetocardiograph for patients with suspected acute coronary syndrome. Emergency Medicine Journal 2020 doi.org/10.1136/emermed-2020-210396

Grassin-Delyle S, Shakur-Still H, Picetti R, Frimley L, Jarman H, Davenport R, McGuiness W, Moss P. et al. Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial. British Journal of Anaesthesia. 2020. BJA-2020-01365 doi.org/10.1016/j.bja.2020.07.058

Hudson A, Gavrilovski M. Adequacy of vascular access in pre-hospital major haemorrhage. London Trauma Conference 2019. Scand J Trauma Resusc Emerg Med 2020, (28)13 doi.org/10.1186/s13049-020-0711-6 [poster]

Henshall C, Greenfield D, Jarman H, Rostron H, Jones H, Barrett S. A nationwide initiative to increase nursing and midwifery research leadership: overview of year one programme development, implementation and evaluation. J Clin Nurs 2020. doi.org/10.1111/jocn.15558

Jarman H, Crouch R, Baxter M, Cole E, Dillane B, Wang C. Frailty in major trauma study (FRAIL-T): a study protocol to determine the feasibility of nurse-led frailty assessment in elderly trauma and the impact on outcome in patients with major trauma BMJ Open 2020;10:e038082. doi.org/10.1136/bmjopen-2020-038082 [open access]

Jones G, Herrera A, Wang C, Moss P, Blazejovaa L. Rapid assessment and discharge, optimizing emergency department bed space allocation: an interrupted time-series analysis. Eur J Emerg Med 2020, 27:64-68 doi:10.1097/MEJ.0000000000000614

Leitch P, Hudson A. Incidence of Hyperoxia in HEMS Trauma Patients. London Trauma Conference 2019. Scand J Trauma Resusc Emerg Med 2020, (28)13 doi.org/10.1186/s13049-020-0711-6 [poster]

Mahmood A, Needham K, Shakur-Still H, Harris T, Jamaluddin S, Davies D, et al. Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients. Emergency Medicine Journal : EMJ 2020 Dec 1,. doi.org/10.1136/emermed-2020-210424

Sivayoham N, Blake L et al. Treatment variables associated with outcome in emergency department with suspected sepsis. Annals of Intensive Care 2020:10,136  doi.org/10.1186/s13613-020-00747-8 [open access]

Publications as collaborators

Brenner A, Belli A, Chaudhri R, Coats T et al. Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial. Crit Care 2020;24, 560 doi.org/10.1186/s13054-020-03243-4 [open access]

The CRASH-3 Intracranial Bleeding Mechanistic Study Collaborators. Tranexamic acid in traumatic brain injury: an explanatory study nested within the CRASH‑3 trial. Eur J Trauma & Emerg Surg 2020 doi.org/10.1007/s00068-020-01316-1 [open access]

The HALT-IT trial collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. The Lancet 2020, 395(10241):1927-1936 doi.org/10.1016/S0140-6736(20)30848-5 [open access]

2020 RCEM virtual scientific conference – poster information

Phil Moss, Marta Pizzorrusso, Tina Uthayakumar, Nina Pieper and Heather Jarman: ACB scoring in the ED: easy as ABC: application of the anticholinergic burden score in ED

2019 publications (alphabetical)

Body R, Twerenbold R, Austin C, Boeddinghaus J, Almashali M, Nestelberger T, Morris N, Badertscher P, McDowell G, Wildi K, Moss P, Jarman H et al. Diagnostic accuracy of a high-sensitivity cardiac troponin assay with a single serum test in the emergency department. Clinical Chemistry 2019; 65(8): 1006-1014 doi.org/10.1373/clinchem.2018.294272

Body R, Almashali M, Morris N, Moss P, Jarman H et al.  Diagnostic accuracy of the T-MACS decision aid with a contemporary point of care troponin assay. Heart 2019; 105(10): 768-774 doi:10.1136/heartjnl-2018-313825

Curry N, Foley C, Wong H, Mora A, Curnow E, Zarankaite A, Hodge R, Hopkins V, Deary A, Ray J, Moss P, Reed M, Kellett S, Davenport R, Stanworth S. The application of a haemorrhage assessment tool in evaluating control of bleeding in a pilot trauma haemorrhage trial. Tranfusion Med 2019;29(6):454-59. doi: 10.1111/tme.12644

Halter M, Kulnik S, Hilton A, Baron A, Garner S, Jarman H. Lay understanding of head injury and when an ambulance might be needed: a mixed methods study. Emergency Medicine Journal 2019;36(10) e11; doi:10.1136/emermed-2019-999abs.24 [poster]

Jarman, H. Commentary: nurses can play a pivotal role in emergency department research. Emergency Nurse, online first: 18 March 2019

Leitch P, Hudson A. Incidence of Hyperoxia in HEMS Trauma Patients. London Trauma Conference 2019. Scand J Trauma Resusc Emerg Med 2020;28(13) doi.org/10.1186/s13049-020-0711-6 [poster]

Reynard C, Morris N, Moss P, Jarman H, Body R. Optimising antiplatelet utilisation in the acute care setting: a novel threshold for medical intervention in suspected acute coronary syndromes. Emergency Medicine Journal 2019, doi:10.1136/emermed-2018-207633 

Sivayoham N, Blake LA, Tharimoopantavida SE, et al. The REDS score: a new scoring system to risk-stratify emergency department suspected sepsis: a derivation and validation study. BMJ Open 2019;9:e030922. doi:10.1136/bmjopen-2019-030922 Link to full text[open access]

Publications as collaborators

The CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 2019;394:1713-23 doi:10.1016/S0140-6736(19)32233-0

Paediatric Emergency Research in the United Kingdom & Ireland (PERUKI) collaborative. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet 2019 doi.org/10.1016/S0140-6736(19)30724-X

Simone L, Lyttle M, Roland D, Stephens D & Schuh S. Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with ronchiolitis.Emergency Medicine Journal 2019;36(3):148-153. doi:10.1136/emermed-2018-208000